Zeta potential of nanoparticles

Sz-100 nanoparticle size & zeta potential analyzer

Electrokinetic potential[1][2] in colloidal dispersions is known as zeta potential. It is usually denoted by the Greek letter zeta (), thus -potential, in colloidal chemistry literature. Volts (V) or millivolts (mV) are the most common units (mV). The electric potential in the interfacial double layer (DL) at the position of the slipping plane relative to a point in the bulk fluid away from the interface is known as the zeta potential. The potential difference between the dispersion medium and the stationary layer of fluid attached to the dispersed particle is referred to as zeta potential.
The net electrical charge found within the region bounded by the slipping plane causes the zeta potential, which is also dependent on the position of that plane. As a result, it is commonly used to determine the magnitude of a charge. In the double layer, however, the zeta potential is not equal to the Stern potential or the electric surface potential, since they are described at different locations. These equality assumptions should be used with caution. Nonetheless, zeta potential is often the only choice for determining double-layer properties.

How to accurately measure the zeta potential of individual

The zeta potential of nanoparticles is proportional to their net surface charge. It’s critical for assessing charged particle colloidal stability and comprehending the system’s success under various conditions.
Visit our Characterization Services landing page for more detail on zeta potential testing and other analytical techniques. For more detail on sample preparation and results interpretation, see our zeta potential video series above.
Both solid-liquid and liquid-liquid colloidal structures have zeta potential, which is a physical property. The Stern layer is a thin layer of ions that surrounds the surface of all scattered particles and has the opposite charge of the particle’s surface. The double layer is a layer of loosely-associated ions of opposite charge to the surface that migrate with the particle through a medium due to Brownian motion or sedimentation. The voltage at the edge of the slipping (shear) plane with respect to the bulk dispersing medium, where ions, molecules, and other agents are no longer connected with a particle’s surface, is known as the zeta potential. Due to repulsive electrostatic forces between particles with like charges, if two adjacent particles have sufficiently high zeta potentials with the same sign, they will not agglomerate.

Tutorial | nanoparticle characterization

Exosomes are nanometer-sized lipid vesicles found in liquid biopsies that have been used as biomarkers for cancer, Alzheimer’s disease, and central nervous system diseases. Exosome-based diagnostics include purification and subsequent size and surface characterization. Purification of the sample, on the other hand, is time-consuming and potentially risky, and no existing method can determine the size and zeta potential from a single measurement. We use a salt gradient in a capillary channel to concentrate exosomes from a dilute solution and calculate their size and zeta potential in a single step. The salt gradient allows particle and fluid transport in opposite directions, trapping particles. The particle concentration rises by more than two orders of magnitude in minutes. Exosome size and surface charge are returned when the spatial distribution of a single or an ensemble of exosomes is suited. Other forms of nanoparticles can be used with our process. A low-cost polymer system is used to create the capillary.

A quick guide to properly measuring zeta potential and

The degree of metal release is influenced by sonication of particle dispersions, as is the outermost surface oxide composition, which also results in an increase in ZP. Surface compositional changes in sonicated and non-sonicated Cu NPs were seen. Overall, it can be concluded that collecting and reporting complementary data on characteristics such as particle size, ZP distributions, blank sample detail, and particle oxide composition allows for accurate measurements and interpretations in the majority of cases.
a brief introduction
Nanoparticles (NPs) are increasingly being used [1–4]. The task of recognizing and evaluating potential risks that these particles may pose to humans and the environment has evolved in tandem with their increased use. It is critical to thoroughly describe the physicochemical properties of NPs before conducting toxicological studies on them, both as pristine particles and after encounters with the biological/environmental media of interest. This type of analysis allows for a better understanding of the toxicological processes at work [5, 6], as well as the prediction of their effects on human health and the environment.