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Vascular calcification in breast

Case 115 mammography left breast vascular calcification

According to a review of over 400 patients published in the June 2019 issue of Clinical Radiology, breast arterial calcification (BAC) seen on mammograms of women with reported angina due to coronary artery disease (CAD) is not an independent indicator of CAD. In reality, BAC had a low diagnostic accuracy for this symptomatic patient group.
BAC is a form of medial artery calcification of small mammary arteries or arterioles that can be seen incidentally on mammography. It has been extensively researched to see whether it could be used as a CAD risk stratification method. Prior research has found a link between BAC and cardiovascular mortality, but no conclusive indicators for using BAC as a risk stratification tool to detect CAD have been established.
The Scottish Computed Tomography of the HEART (SCOT-HEART) study, a multi-center randomized controlled trial of coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease, was used by a multi-institutional team of researchers from Edinburgh. The researchers used CCTA to evaluate the incidence of BAC in patients who had mammograms, as well as the relationship between BAC and cardiovascular risk factors, coronary artery calcification, and CAD disease.

Bi-rads category 3 comparison (radiology, december

For the first time, data from this study show a correlation between the amount of calcium in the breast arteries—which can be seen on digital mammography—and the extent of calcium accumulation in the coronary arteries. CAC, or coronary arterial calcification, is a very early symptom of cardiovascular disease. Importantly, breast arterial calcification tends to be an equal or greater risk factor for CAC than other well-known cardiovascular risk factors like high cholesterol, high blood pressure, and diabetes. Researchers said these findings provide a more direct connection between the degree of calcified plaque in the mammary and coronary arteries, as well as a comparison to standard risk evaluation. Previous studies had shown a correlation between breast arterial calcification and atherosclerotic disease—even heart attack, stroke, and other cardiovascular disease events—but these findings provide a more direct relationship between the extent of calcified plaque in the mammary and coronary arteries, as well as a comparison to standard risk evaluation.
“Many women, especially young women, are unaware of their coronary artery health. According to our findings, if a mammogram reveals breast arterial calcifications, it may be a red flag—an ‘aha’ moment—that she might also have plaque in her coronary arteries,” said Harvey Hecht, M.D., professor at Mount Sinai’s Icahn School of Medicine and director of cardiovascular imaging at Mount Sinai St. Luke’s Hospital, and study lead author.

Treating calcified lesions using the shockwave

Breast arterial calcification (BAC), an incidental finding on 3–29% of mammograms, can be used to test for coronary artery disease, according to growing proof (CAD). We performed a systematic analysis to evaluate the links between BAC and CAD, as well as their risk factors (hypertension, hypercholesterolemia, diabetes mellitus and smoking).
Up until February 18, 2020, the MEDLINE and EMBASE databases, as well as the references of related journals, were searched for English language studies that examined the associations between BAC and CAD and their risk factors. A single reviewer extracted all data and evaluated study accuracy, with additional independent reviewer verification if necessary. The OR was 2.61 (95 percent CI 2.12–3.21; I2 = 71 percent) across 31 studies (n = 35,583; 3 longitudinal and 28 cross-sectional studies) that looked at the connection between BAC and CAD. A sub-analysis of research using the 4- (4 studies) or 12-point scale systems (3 studies) to grade BAC severity found a connection between CAD and moderate-severe BAC (OR 4.83 (95 percent CI 1.50–15.54) and OR 2.95 (95 percent CI 1.49–5.84), but not mild BAC (OR 2.04 (95 percent CI 0.82–5.05) and OR 1.08 (95 percent CI 0.42–2.75), respectively. Hypertension (42 studies; n = 32,646; OR 1.80; 95 percent CI 1.47–2.21; I2 = 85 percent ) and diabetes mellitus (51 studies; n = 53,464; OR 2.17; 95 percent CI 1.82–2.59; I2 = 75 percent ) were both linked to BAC, but not hypercholesterolemia (OR 1.31; 95 percent CI 0.97–1.77; I2 = 67 percent ). Smoking was found to be inversely related to blood alcohol concentration (35 studies; n = 40,002; OR 0.54; 95 percent CI 0.42–0.70; I2 = 83 percent). The majority of the women in the studies were symptomatic. There was significant variability, and publication bias may be present.

Medical vocabulary: what does vascular calcification mean

BackgroundBecause cardiovascular disease is one of the leading causes of death, the presence of breast arterial calcifications on annual mammography screening may predict the likelihood of potential cardiovascular problems.

Aha : vascular discovery: from genes to medicinescientific

Conclusions

Nejmvideo

The 100 female patients were split into two groups based on their ages: the first group was 40-60 years old, and the second group was 61-80 years old. With a significant p value = 0.022, there was an increased percentage of cardiac cases among the BAC-positive patients in the 2nd group, proving that there was an association between the presence of BAC and being a cardiac case in the 2nd group, as opposed to the 1st group, which showed no correlation. final thoughts The discovery of breast arterial calcification in mammography in females over 60 years of age necessitates a more thorough assessment of their coronary atherosclerotic state and risk of developing serious coronary artery disease in the future.
Methodologies
In this study, screening mammography was performed on 100 women aged 40 to 80 years, with an average age of 56.8 years, who had previously undergone various cardiac investigations for the assessment of coronary cardiac disease/risk. Mammography was used to assess the prevalence of BAC, the number of affected vessels, and the distribution of calcification in the vessel wall. The participants were asked about diabetes, hypertension, and dyslipidemia, all of which are cardiovascular risk factors. Cardiac catheterization, CT coronary angiography, and a thallium scan were among the cardiac tests performed. Criteria for inclusion Female patients aged 40 to 80 years old who had undergone cardiac investigations (cardiac catheterization, CT coronary angiography, or thallium scan) with either positive or negative results for coronary cardiac disease/risk were included in our research. Criteria for exclusion There isn’t any. Possibility of danger There isn’t any risk. Techniques Any of the patients were subjected to the following procedures: