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Teva Pharmaceutical Industries’ Quartette, which the Israeli firm defines as “the next generation of extended-regimen oral contraceptives,” has been approved by the US Food and Drug Administration. Quartette (levonorgestrel/ethinyl estradiol and ethinyl estradiol) tablets, which are intended to reduce breakthrough bleeding (BTB) between cycles, have been given the green light. The approval is focused primarily on results from a Phase III study that included over 3,000 women and found the medication to be 97 percent effective at preventing pregnancy. According to the business, BTB “can be experienced with any birth control pill, particularly within the first few months, and is one of the reasons a large number of women discontinue extended regimens,” according to James Simon, professor of obstetrics and gynecology at George Washington University School of Medicine. He clarified that the oestrogen in Quartette rises at different times “and provides four short light periods a year,” while BTB decreases over time, “which may help promote patient adherence.” Quartette is “a beautifully differentiated product…and is an example of our commitment to offering a range of contraceptive and family planning choices,” according to Jill DeSimone, head of Teva’s women’s health company.
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Birth control pills are available in a number of different formulations. The key distinction is between progestogen-only pills and combination oral contraceptive pills, which contain both estrogens and synthetic progestogens (progestins). Combined oral contraceptive pills are also available in a variety of forms, including different estrogen doses and whether the estrogen or progestogen dose varies from week to week.
Combination pills normally operate by stopping eggs from being released by the ovaries (ovulation). They also thicken cervical mucus, which prevents sperm from entering the uterus and forming a bond with an egg. The uterine lining is often thinned by hormones in combination and progestogen-only tablets. By interfering with the implantation of a blastocyst, this may prevent pregnancy.
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