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Skeletal muscle fiber model

Skeletal muscle fiber model

Skeletal muscle model project

Realistic simulations of detailed, biophysics-based, multi-scale models often necessitate extremely high resolution and, as a result, large-scale computing resources. Existing simulation environments, particularly for biomedical applications, are usually designed to allow for high model versatility and generality. For large-scale simulations, however, flexibility and model construction are often a limiting factor. As a result, new models are often reviewed and run on small-scale computing platforms. We present an approach to upgrading an existing muscle simulation architecture from a moderately parallel version to a massively parallel one that scales both in terms of problem size and the number of parallel processes, using a comprehensive biophysics-based, chemo-electromechanical skeletal muscle model and the international open-source software library OpenCMISS as an example. We explore various modeling, algorithmic, and implementational aspects for this reason. We show enhancements that resolve both numerical and parallel scalability. Furthermore, our solution includes a novel visualization environment based on the MegaMol system that can handle large quantities of simulated data. At the High Performance Computing Center Stuttgart’s Tier-1 supercomputer HazelHen, we present the findings of a variety of scaling tests (HLRS). We reduce overall runtime by up to 2.6 times and achieve reasonable scalability with up to 768 cores.

Sarcomere model labeled

The effects of redistribution of spatial activation patterns in young and old muscle were investigated using a micromechanical finite element muscle model. To model a fascicle, the geometry consisted of a bundle of 19 active muscle fibers encased in endomysium sheets and surrounded by passive tissue. Combinations of the 19 active muscle fibers were used to create force. Unbalanced strains were seen in the spacial clustering of muscle fibers modeled in this study, implying that tissue damage at higher strain levels can occur during higher levels of activation and/or dynamic conditions. One of the effects of motor unit failure and reinnervation associated with aging is these patterns of motor unit remodeling. While there were no obvious quantitative differences in force transmission between old and young adults, the patterns of stress and strain distribution were altered, implying that an unequal distribution of forces may occur within the fascicle, potentially providing a mechanism for muscle injury in older muscles.

Skeletal muscle fiber model labeled

Skeletal muscle (also known as striated muscle) is one of three main muscle types, the other two being cardiac muscle and smooth muscle. It is a form of striated muscle tissue that is regulated by the somatic nervous system on a voluntary basis. 1st Tendons are collagen fiber bundles that connect most skeletal muscles to bones.
Muscle fibers are numerous bundles of muscle fascicles of muscle cells that make up skeletal muscle. Fasciae are connective tissue layers that cover the fibers and muscles. Myogenesis is the mechanism by which muscle fibers are produced by the fusion of developmental myoblasts. Muscle fibers are cylindrical in shape and have several nuclei. They have multiple mitochondria to satisfy their energy requirements.
Myofibrils are the building blocks of muscle fibers. Myofibrils are made up of actin and myosin filaments that are replicated in sarcomeres, which are the muscle fiber’s basic functional units. The sarcomere is responsible for skeletal muscle’s striated appearance and provides the essential machinery for muscle contraction.

Neuromuscular junction

Each skeletal muscle is an organ made up of a variety of interconnected tissues. Skeletal muscle fibers, blood vessels, nerve fibers, and connective tissue are among these tissues. Each skeletal muscle has three layers of connective tissue that surround it, give it structure, and compartmentalize the muscle fibers inside it (Figure 10.2.1). The epimysium, a sheath of thick, irregular connective tissue that surrounds each muscle, allows it to contract and move powerfully while preserving structural integrity. Muscle is therefore separated from other tissues and organs in the area by the epimysium, allowing it to move independently.
Muscle fibers are grouped into fascicles, which are surrounded by a middle layer of connective tissue called the perimysium, within each skeletal muscle. This fascicular organization is normal in limb muscles; it enables the nervous system to activate a subset of muscle fibers within a fascicle of the muscle to initiate a particular movement. Each muscle fiber is encased in a thin connective tissue layer of collagen and reticular fibers called the endomysium within each fascicle. The endomysium surrounds the cells’ extracellular matrix and aids in the transfer of force produced by muscle fibers to the tendons.