Poorly differentiated thyroid carcinoma
Poorly differentiated thyroid carcinoma immunohistochemistry
The histologic characteristics of poorly differentiated thyroid carcinomas are shown in Figure 1. Fig. 2: Thyroid carcinomas with low differentiation occurring in the encapsulated follicular form of papillary thyroid carcinoma is seen in Cases 3 and 6. DICER1 somatic mutations in the RNase IIIb and non-RNase IIIb domains (Fig. 3). Case 2 had one germline mutation in intron 6 involving a cryptic splice site (Fig. 4).
eFigure 1 in the Supplementary Appendix, and Supplemental Table 8 in the Supplementary Appendix
Tables 1–7 of the appendices
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R.D. Chernock, B. Rivera, N. Borrelli, and others DICER1 mutations distinguish poorly differentiated thyroid carcinoma of childhood and adolescence as a distinct entity.
Poorly differentiated thyroid cancer lungs
Poorly differentiated thyroid cancer (PDTC) is a rare but deadly form of thyroid cancer (TC) that is the leading cause of death among non-anaplastic follicular cell-derived TC patients. Despite the fact that the Turin parameters are well known, the pathological characteristics that could be used as diagnostic and prognostic factors are still debated.
Between 2000 and 2018, 49 consecutive PDTC cases were discovered in a single cancer center. We looked at how the existence of atypical mitoses, the amount of necrosis, and insulin-like growth factor-II mRNA-binding protein 3 immunostaining affected the survival of PDTC patients. The Kaplan-Meier approach was used to measure overall survival (OS) and disease-specific survival (DSS).
The insular pattern of growth was seen in 34 (69.4%) of the 49 PDTC. The median poorly differentiated region was 95% (range 1–100), and 30 (61.2%) of the patients had a predominant insular area (>50%). At a median follow-up of 57 months, the 5-year OS and DSS concentrations were 60.6 percent and 64.3 percent, respectively. Tumor size >4 cm, atypical mitoses, Ki-67 >5%, and thyroglobulin (Tg)-negative immunostaining were all linked to a higher risk of PDTC-related death in a univariate study. In multivariate analysis, atypical mitoses and Tg negativity were found to be independent factors of lower DSS. When patients with insular and prevalent insular areas had atypical mitoses, they had a 3- to 6-fold higher risk of PDTC death.
Poorly differentiated thyroid cancer staging
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Outcomes in patients with poorly differentiated thyroid carcinoma
Poorly differentiated thyroid carcinomas (PDTCs) are an unusual subtype of thyroid carcinoma that lies between well-differentiated papillary/follicular and anaplastic thyroid carcinomas biologically (ATCs).
Poorly differentiated thyroid carcinoma cytology
The detection of both traditional and oncocytic poorly differentiated thyroid carcinomas is complex and often overlooked in daily practice. The new WHO requirements for diagnosing PDTCs are based on the outcomes of a Turin consensus meeting in 2006. Even a small poorly differentiated portion accounting for 10% of a given carcinoma has a major impact on patient prognosis, and the oncocytic subtype can even have a worse prognosis. Immunohistochemistry isn’t very useful; it’s often used to rule out a medullary thyroid carcinoma with calcitonin staining and to confirm a follicular cell of origin with thyroglobulin staining. Because of the principle of stepwise dedifferentiation, there is a lot of variation between different thyroid carcinoma subtypes in terms of molecular alterations like BRAF, RAS, CTNNB1, TP53, and others. As a result, there is currently no distinct molecular tumor profile available. PDTCs have a distinct miRNA signature that distinguishes them from other thyroid cancers. The average time between relapses is less than a year, and about half of patients die from the disease. In these difficult-to-treat carcinomas, modern tyrosine kinase inhibitors, in combination with effective molecular diagnostics, offer new possibilities.