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Can polymyositis cause death

Can polymyositis cause death

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Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases that affect multiple organs and cause muscular and cutaneous disorders, as well as interstitial lung disease (ILD) and cancer. However, there is a scarcity of data on the outcomes and related causes for PM/DM patients who are hospitalized.
From 2008 to 2014, we looked back at the medical records of PM/DM patients who were admitted to a Chinese tertiary referral hospital (Peking Union Medical College Hospital, PUMCH). There were 63 patients in the deceased party, all of whom had a “deceased discharge” status or were assumed to have died within two weeks of hospital discharge. Retrospective analysis of demographic statistics, clinical manifestations, and direct causes of death was performed. From 982 inpatients consecutively admitted to the same center during the same time, medical records for 126 age- and sex-matched PM/DM patients were chosen as controls. In addition to comparing clinical manifestations between the two classes, binary logistic regression was used to investigate PM/DM mortality risk factors.

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Polymyositis (PM) is a form of inflammatory myopathy (chronic muscle inflammation) that is similar to dermatomyositis and inclusion body myositis. Its name (poly- + myos- + -itis) means “inflammation of many muscles.” Polymyositis causes inflammation primarily in the endomysial layer of skeletal muscle, while dermatomyositis causes inflammation primarily in the perimysial layer of skeletal muscle. 1st
Polymyositis is characterized by weakness and/or loss of muscle mass in the proximal musculature, as well as neck and torso flexion.
1st These symptoms can also be linked to severe pain in these areas. The hip extensors are often affected, making climbing stairs and rising from a seated position particularly difficult. Polymyositis does not have the skin involvement of dermatomyositis. Dysphagia (difficulty swallowing) or other esophageal motility disorders affect up to a third of patients. There may be a low-grade fever and swollen lymph nodes. Advanced polymyositis and inclusion body myositis can cause foot drop in one or both feet. Interstitial lung disease (ILD) and cardiac disease, such as heart failure and conduction disorders, are examples of polymyositis’ systemic involvement. [two]

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X-linked myotubular myopathy

The writers announce that they do not have any conflicting interests.

Polymyositis l dermatomyositis l juvenile dermatomyositis

Contributions of the authors

Clostridial myositis

JMPS conducted the regression analysis, CEP built all software systems to process multiple cause-of-death, and DCCS and EIS revised the manuscript. AHS engaged in the study design, data collection, analysis, and interpretation, and drafted the manuscript. The final manuscript was read and accepted by all contributors. Initial image files submitted by authors The authors’ original image submission files are linked below.
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Inclusion body myositis (IBM) is a debilitating inflammatory myopathy that affects people over the age of 50. According to two small studies conducted in the 1980s and 1990s, every 1 million Americans should expect 1 to nearly 8 annual incidences of IBM. 1
IBM is one of the idiopathic inflammatory myopathies, along with polymyositis, dermatomyositis, and autoimmune necrotizing myopathy (a group of disorders characterized by inflammation of the skeletal muscle). Inflammatory cells infiltrate muscle tissue and cluster in the spaces between muscle fibers. Multiple inclusion bodies containing cellular material of dead tissue can be seen in a biopsy taken from a patient with IBM. IBM is named for the “bodies,” which are clumps of discarded cellular material that accumulate in muscle tissues. Immune cells congregate in the vicinity of these bodies. 1
There are several hereditary variants of IBM in which inflammation is not a major factor. As a consequence, these types are often referred to as inclusion-body myopathy (muscle disorder), omitting the word “itis” from the disease name to reflect the lack of inflammation. See Causes/Inheritance for more information.