Calcium channel blockers and heart failure

Calcium channel blockers and heart failure

Heart failure | pharmacology (ace, arbs, beta blockers

A combination of an ACE inhibitor (or an AT1 blocking agent), a diuretic, and a beta-blocker is commonly used to treat congestive heart failure. Despite obtaining optimal care with these medications, some patients remain symptomatic. Nitrates or calcium-channel blockers can help relieve symptoms in patients who also have coronary heart disease. As a result, the aim of our research is to see whether a second-generation calcium-channel blocker, amlodipine, will help patients with chronic heart failure who are still symptomatic after receiving the best care.
The use of an ACE inhibitor in combination with digoxin and a diuretic has been shown to reduce morbidity and mortality in patients with congestive heart failure. However, 40% of these patients continue to have symptoms. Calcium channel blockers are used in patients with chronic heart failure because of their vasodilating, anti-ischemic, and ability to minimize left ventricular diastolic dysfunction. Our goal is to see how a 3-month amlodipine treatment affects regional and systemic hemodynamic, hormonal, and vascular effects, as well as stress tolerance. For a 3-month cycle, patients with stable chronic heart failure (III/IV NYHA) who are being treated with a combination of enalapril, furosemide, and digoxin will be randomized to receive amlodipine 5 or 10 mg or a placebo.

Calcium channel blockers | mechanism of action, indications

Calcium channel blockers (CCBs), especially dihydropyridine (DHP) agents, have a central role in the treatment of hypertension and cardiovascular disease, according to new proof (CVD). We look at recent studies, systematic reviews, and meta-analyses that contradict the results of a single, well-publicized, earlier unfavorable meta-analysis. According to these new studies, CCBs are effective and safe antihypertensive agents that substantially reduce the risk of cerebrovascular and cardiovascular events, as well as having potential kidney benefits. As a result, since most hypertensive patients need more than one agent to meet prescribed blood pressure (BP) targets, there are compelling reasons for including a CCB in the mix.
CCBs have been shown in several comparative studies to be at least as effective as other antihypertensive agents. In the Intervention as a Goal in Hypertension Treatment (INSIGHT) study, nifedipine gastrointestinal therapeutic system (GITS) achieved BP reductions comparable to co-amilozide in hypertensive patients with at least one additional cardiovascular risk factor. In the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), amlodipine, lisinopril, and chlorthalidone all reduced blood pressure to similar levels in a similar patient population: while 5-year systolic BP levels were 0.8mmHg higher in the amlodipine community (p=0.03), 5-year diastolic BP was slightly lower (0.8mmHg, BP values were lower in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) in patients receiving the amlodipine-based rather than the atenolol-based regimen (amlodipine, adding perindopril as needed versus atenolol, adding bendroflumethiazide as needed).

Cardiovascular pharmacology – 02 – calcium channel blockers

Morbidity and mortality in long-term research 34 Better planned trials, with a larger number of participants, control groups, and longer follow-up periods were possible in line with the age of evidence-based medicine. Since these experiments were made to determine survival time in cardiovascular disease immediately following acute myocardial infarction, the first three of these 27-29 implicitly focused on the possible impact of calcium antagonists on heart failure. Since the research only looked at a small number of ischemic patients, they were constrained. As a result, they did not reflect dilated cardiomyopathy in general. The use of calcium antagonists was found to be unfavorable in patient subgroups with congestive heart failure (table II).
Other research 30-33 from 1996 onwards identified the impact of calcium antagonists on the morbidity and mortality ratios of congestive heart failure patients who were not in the acute myocardial infarction community. In cases of dilated cardiomyopathy, none of these studies provided data compelling enough to lead to a change in the current clinical approach. Only the PRAISE study 32 observed a substantial reduction in morbidity and mortality ratios in a nonischemic subgroup of patients after using amlodipine, a finding that differed from that recorded for the long-half-life dihydropyridines 34. (table III).

Pharmacology calcium channel blockers – antihypertensive

According to a new study by Penn State College of Medicine researchers, L-type calcium channel blockers (LCCBs), the most commonly used drugs for treating hypertension, can damage the heart as much as they support it.

Calcium channel blockers and hypertension (pharmacology

30th of July, 2020

Calcium channel blockers & cardiovascular pharmacology

Penn State University’s College of Medicine Breaking News
Professor of cellular and molecular physiology Mohamed Trebak, PhD
LCCBs induce improvements in blood vessels, known as vascular remodeling, in rats and human cells in vitro, according to the research team, which was led by Mohamed Trebak, professor of cellular and molecular physiology.
They looked at epidemiological data and discovered that LCCBs were related to a higher risk of heart failure. The results, which were published in Proceedings of the National Academy of Sciences on July 8, indicate that patients, especially older adults and those with advanced hypertension, should be prescribed these drugs with caution.
“Hypertension affects approximately half of all adults in the United States – or just over 100 million people – and its prevalence is rising; by 2025, the disease is projected to affect 1.56 billion people worldwide,” Trebak said. “Despite the fact that L-type calcium channel blockers are one of the most commonly prescribed medications to treat hypertension, we have discovered that they can cause the same type of harm that they are supposed to prevent.”