Bladder cancer mets to bone
Dr. petrylak on the results of the ev-103 trial in bladder
The patient’s treating physicians were MGG, JLH, and AR. The study was planned by DT and AD, and the manuscript was written by them. The radiologic specialist was VD. The final manuscript was read and accepted by all contributors.
Pfizer, Novartis, and MSD also charged Gross-goupil consulting fees or honoraria. Ravaud is a member of Pfizer, Novartis, and BMS’s global, European, and/or French advisory boards in RCC, and has obtained institutional grant funding from Pfizer and Novartis, as well as housing and travel support for meetings from Pfizer, Novartis, and BMS. The remaining writers announce that they have no competing interests.
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Bladder cancer: basics of diagnosis, workup, pathology, and
We reviewed the data in our files to assess the incidence of bone metastasis in muscle invasive bladder cancer patients, in order to resolve the importance of using isotopic bone scan in the regular staging work-up of such patients. The incidence of subsequent bone metastasis development over the course of the disease’s natural history was also investigated.
Between January 2000 and December 2001, 179 files of consecutive bladder cancer patients who presented to the National Cancer Institute, Cairo University, were checked to determine the percentage of patients with positive bone scans at the time of presentation, as well as the development of distant metastases and bone metastasis in these patients’ records.
26 (14.5%) of the 179 patients had bone metastasis at the time of diagnosis, which had a statistically important association with the depth of muscle invasion: 61.5 percent of the metastatic cases had deep muscle invasion, 19.2 percent had superficial muscle invasion, and 7.7% had no muscle invasion (p=0.000). Transitional cell carcinoma was found in 92.3 percent of the patients, while squamous cell carcinoma was found in just 7.7% (p=0.036). After surgery, the median 3-year incidence of bone-metastasis in non-metastatic patients was 19.4 +/- 4.4 percent. In the 153 patients, the cumulative 3-year bone metastasis incidence increased with increasing clinical level, from 8.4 +/- 8% for c-stage 2 to 49.1 +/- 18.5 percent for c-stage 4 (p=0.046). In the 130 patients who underwent surgery, the frequency of the p-category of tumor increased with higher p-stages (p=0.006). Though pelvic nodal involvement was not related to a statistically significant increase in the incidence of bone metastases, when it was included as one of the three risk factors (grade>3, p (3) 4a, and LN positive at surgery), there was a statistically significant difference in the incidence between patients with no risk factors, one risk factor, and two or more risk factors.
Dr. hwang on the state of treatment in metastatic
Bladder cancer tends to cause severe morbidity and mortality among those who are affected. There have been few advances in the treatment of metastatic bladder cancer. Chemotherapy with platinum-based regimens is still the first-line treatment of choice. Alternative regimes have not been shown to provide a survival benefit in research. As a single agent or in conjunction with chemotherapy, targeted therapies can be beneficial. Patients’ quality of life is impacted by symptoms caused by metastatic bladder cancer, so holistic treatment is critical. Radiotherapy, bisphosphonates, and the presence of specialist palliative care providers are examples of such management. The current management of metastatic bladder cancer, possible potential treatment modalities, and the evidence to support the management strategies will be discussed in this study.
Bladder cancer was the seventh most common cancer in the UK in 2008, with over 10,000 new cases. Muscle-invasive bladder cancers (MIBC) account for a quarter of these cases [1–5]. At the time of diagnosis, about 5% of patients had metastatic bladder cancer . Transitional cell carcinoma (TCC) is the most common histological type of bladder cancer in the UK, although there are other forms as well, such as squamous cell carcinoma, adenocarcinoma, and less commonly small cell and small cell and sarcoma. Prevalence is influenced by factors such as geography and underlying aetiology all over the world . The current management of patients with metastatic bladder cancer, primarily of the TCC type, and the evidence to support that management will be discussed in this study.
Understanding bone metastases formation in patients with
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Zhang C, Liu L, Tao F, Guo X, Feng G, Chen F, Xu Y, Li L, Han X, Baklaushev VP, Bryukhovetskiy AS, Wang X, Wang G. Zhang C, Liu L, Tao F, Guo X, Feng G, Chen F, Xu Y, Li L, Han X, Baklaushev VP, Bryukhovetskiy A Population-Based Study of Bone Metastases in Newly Diagnosed Metastatic Bladder Cancer. 4706-4711. doi:10.7150/jca.28706. J Cancer 2018; 9(24):4706-4711. It’s available at (Click on the image to enlarge.) Surveillance, Epidemiology, and End Results (SEER) is an open-access database maintained by the National Cancer Institute that contains cancer incidence and survival data from 18 existing cancer registries throughout the United States, representing roughly 30% of the total US population. SEER is a commonly used database that contains full demographic and clinical data as well as long-term, high-quality follow-up for determining cancer epidemiological characteristics all over the world. The current study made use of the SEER database. The frequency of BM with initial BC was studied, as well as the risk factors. Meanwhile, survival rates and prognostic factors for BC patients with BM at diagnosis were compiled.